Koncentrering af STAT3 signalvejen i de fleste kræftformer: funktion af kunstige og rene hæmmere
Skilttransducere og aktivatorer af transkription (STAT’er) omfatter en husstand af cytoplasmatiske transkriptionskomponenter, som medierer intracellulær signalering, der normalt genereres ved cellegulvreceptorer og derved transmitterer den til kernen.
En hel del undersøgelser har vist konstitutiv aktivering af STAT3 i alle former for humane tumorer sammen med hæmatologiske maligne lidelser (leukæmi, lymfomer og et antal myelomer) ud over adskillige stabile tumorer (beslægtet med hoved og hals, bryst, lunge, mave) , hepatocellulære kræftformer, kræft- og prostatacancer.
Der er et robust bevis for at rådgive om, at afvigende STAT3-signalering fremmer initiering og udvikling af humane kræft ved både at hæmme apoptose eller inducere celleproliferation, angiogenese, invasion og metastase. Undertrykkelse af STAT3-aktivering fører til induktion af apoptose i tumorceller, og følgelig er dets farmakologiske modulation af tyrosinkinaseinhibitorer, antisense-oligonukleotider, lokke-nukleotider, dominerende ugunstige proteiner, RNA-interferens og kemoprevensive mæglere blevet anvendt til at undertrykke spredning af forskellige menneskelige mest kræftceller i tradition og tumorigenicitet in vivo.
elisa kits
Ikke desto mindre forbliver identifikationen og væksten af ny medicin, der kan målrette en dereguleret STAT3-aktivering, et nødvendigt videnskabeligt og medicinsk problem. Denne vurdering præsenterer beviset for væsentlige roller af STAT3 i onkogenese og diskuterer potentialet for vækst af nye flest kræftformerterapier baseret hovedsageligt på mekanistisk forståelse af STAT3-signaleringskaskade.
Description: BCL2L1 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 232 amino acids (1-209 a.a) and having a molecular mass of 25.8kDa. BCL2L1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Description: BAG2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 231 amino acids (1-211 a.a.) and having a molecular mass of 25.9kDa. The BAG2 is purified by proprietary chromatographic techniques.
Recombinant Human Bcl2 Modifying Factor, Isoform 3
Description: Recombinant Human BCL2 produced in E.coli cells is a non-glycosylated, homodimeric protein containing 210 amino acid chain and having a molecular mass of 23.2kDa. The Human BCL2 is purified by proprietary chromatographic techniques.
Recombinant (E.Coli) Human BCL2-Related Protein A1
Description: BCL2A1 Human Recombinant produced in E. coli is a single polypeptide chain containing 176 amino acids (1-152) and having a molecular mass of 20.2kDa.
Description: BCL2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing amino acids 1-211 and having a molecular mass of 25.4 kDa. The BCL2 is fused to a 20 a.a. His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Description: BAG3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 595 amino acids (1-575 a.a.) and having a molecular mass of 63.7 kDa. The BAG3 protein is fused to a 20 amino acid His Tag at N-terminus and purified by standard chromatogrpahy techniques.
BAG1 BCL2-Associated Athanogene 1 Human Recombinant Protein
Description: BAG1 Human Recombinant produced in E.Coli is a single, non-glycosylated,_x000D_ polypeptide chain containing 230 amino acids (1-230 a.a.) and having a molecular mass of 25.9 kDa. BAG1 protein is purified by standard chromatography.
Recombinant Human BAX/Bcl-2-Like Protein 4/BCL2L4 (N, C-6His)
Description: Bcl2 modifying factor Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 144 amino acids (1-129 a.a.) and having a molecular mass of 15.6 kDa.;The Bcl2 modifying factor is fused to 15 amino acid His Tag at Nterminus and purified by proprietary chromatographic techniques.
Recombinant Human BMF/ Bcl2 modifying factor Protein, GST, E.coli-1mg
Description: Recombinant Human Stathmin Like-2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 142 amino acids (39-179 a.a) and having a molecular mass of 16.4 kDa. ;STMN2 is purified by conventional chromatography techniques.
Først leveret til videnskabelig betragtning som infektiøse kræftfremkaldende mæglere praktisk talt 80 år i fortiden, er retrovirus i stil i moderne biologi af mange årsager.
(i) Virussens livscyklus indeholder et antal begivenheder – i eksplicit, omvendt transkription af det virale RNA-genom i DNA, ordnet integration af viralt DNA i værtskromosomer og anvendelse af værtsmekanismer til genekspression som respons på virale signaler- -som er stort set informative om eukaryote celler og vira.
(ii) Retroviral onkogenese er normalt afhængig af transduktion eller indsættelsesaktivering af mobile gener, og isolering af disse gener har tilbudt den videnskabelige gruppe med de fleste af de molekylære elementer, der nu er involveret i styringen af regelmæssig fremgang og hos de fleste kræftformer hos mennesker.
(iii) Retrovirus indeholder mange nødvendige veterinære patogener og to for nylig fundne humane patogener, de forårsagende mæglere af det erhvervede immundefekt syndrom (AIDS) og voksen T-celle leukæmi / lymfom.
(iv) Retrovirus er genetiske vektorer i naturen og kan modificeres til at fungere genetiske vektorer for hver eksperimentelle og terapeutiske funktioner.
(v) Indsættelse af retroviralt DNA i værtskromosomer kan anvendes til at markere cellelinier og til at fremstille udviklingsmutanter. Fremskridt inden for disse og forskellige områder inden for retrovirus-relateret biologi har været enorm gennem de foregående tyve år, men mange fornuftige og teoretiske problemer er dog stadig at løse.
IMGT, den verdensomspændende ImMunoGeneTics-database.
IMGT, den verdensomspændende ImMunoGeneTics-database, er en højkvalitets indbygget database, der specialiserer sig i immunoglobuliner (Ig), T-celle-receptorer (TcR) og Main Histocompatibility Complicated (MHC) molekyler af alle hvirveldyrarter, oprettet i 1989 af Marie-Paule Lefranc , Université Montpellier II, CNRS, Montpellier, Frankrig ([email protected]).
IMGT indeholder tre databaser: LIGM-DB, en komplet database over Ig og TcR, MHC / HLA-DB og PRIMER-DB (de sidste to i vækst); en enhed, IMGT / DNAPLOT, udviklet til sekvensevaluering og justeringer; og ekspertiseret viden baseret hovedsageligt på det IMGT-videnskabelige diagram, IMGT-repertoiret. Ved sin førsteklasses kvalitet og sin enkle videnfordeling har IMGT nødvendige implikationer i medicinsk analyse (repertoire i autoimmune sygdomme, AIDS, leukemier, lymfomer), terapeutiske tilgange (antistofudvikling), genomvariation og genomudviklingsforskning.
IMGT, det verdensomspændende ImMunoGeneTics datasystem.
Det verdensomspændende ImMunoGeneTics-datasystem (IMGT), oprettet i 1989, af Laboratoire d’ImmunoGenetique Moleculaire LIGM (Universite Montpellier II og CNRS) i Montpellier, Frankrig, er en indbygget informations nyttig ressource af høj kvalitet, der er specialiseret inden for immunoglobulinerne (IGs) ), T-cellereceptorer (TR’er), kompliceret histokompatibilitet kompliceret (MHC) for humane og forskellige hvirveldyr og associerede proteiner fra immunprogrammerne (RPI), der hører til immunglobulinsuperfamilien (IgSF) og til MHC superfamilien (MhcSF).
IMGT indeholder et antal sekvensdatabaser (IMGT / LIGM-DB, IMGT / PRIMER-DB, IMGT / PROTEIN-DB og IMGT / MHC-DB), en genomdatabase (IMGT / GENE-DB) og en tredimensionel (3D ) konstruktionsdatabase (IMGT / 3Dstructure-DB), internetkilder omfattende 8000 HTML-sider (IMGT).
Recombinant human B-cell CLL/lymphoma 9-like protein
Description: Bcl-2 Des BH4 domain (10-30 residues) Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 197 amino acids 1-9 and 31-218.;The Bcl-2 is expressed as His-Tag fusion protein and purified by proprietary chromatographic techniques.
Description: BCL10 Human Recombinant produced in E. coli is a single polypeptide chain containing 257 amino acids (1-233) and having a molecular mass of 28.8kDa (molecular weight on SDS-PAGE will appear higher).;BCL10 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
BCL7C B-cell CLL/lymphoma 7C Human Recombinant Protein
Description: BCL7C Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 240 amino acids (1-217 a.a) and having a molecular mass of 25.9kDa (Molecular size on SDS-PAGE will appear higher).;BCL7C is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
BCL7A B-cell CLL/lymphoma 7A Human Recombinant Protein
Description: BCL7A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 233 amino acids (1-210 a.a.) and having a molecular mass of 25.2kDa (Molecular size on SDS-PAGE will appear higher).;BCL7A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Recombinant B-Cell CLL/Lymphoma 2 Like Protein (Bcl2L)
Description: TCL1B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 151 amino acids (1-128a.a) and having a molecular mass of 17.2kDa. TCL1B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TCL1A T-cell Leukemia/Lymphoma 1A Human Recombinant Protein
Description: TCL1A Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 114 amino acids (1-114 a.a.) and having a molecular mass of 13.4kDa.;The TCL1A is purified by proprietary chromatographic techniques.
Recombinant T-Cell Leukemia/Lymphoma Protein 1A (TCL1A)
Description: A sandwich ELISA for quantitative measurement of Human B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Human B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human B cell CLL/lymphoma 9 protein(BCL9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human B cell CLL/lymphoma 9 protein(BCL9) ELISA kit
Description: A competitive ELISA for quantitative measurement of Human B cell CLL/lymphoma 9 protein(BCL9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human B cell CLL/lymphoma 9 protein(BCL9) ELISA kit
Description: A competitive ELISA for quantitative measurement of Human B cell CLL/lymphoma 9 protein(BCL9) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human B- cell CLL/lymphoma 9 protein, BCL9 ELISA KIT
Description: A competitive ELISA for quantitative measurement of Human B cell CLL/lymphoma 7 protein family member B(BCL7B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human B cell CLL/lymphoma 7 protein family member B(BCL7B) ELISA kit
Description: A competitive ELISA for quantitative measurement of Human B cell CLL/lymphoma 7 protein family member B(BCL7B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human B cell CLL/lymphoma 7 protein family member B(BCL7B) ELISA kit
Description: A competitive ELISA for quantitative measurement of Human B cell CLL/lymphoma 7 protein family member B(BCL7B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human B cell CLL/lymphoma 6 member B protein(BCL6B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human B cell CLL/lymphoma 6 member B protein(BCL6B) ELISA kit
Description: A competitive ELISA for quantitative measurement of Human B cell CLL/lymphoma 6 member B protein(BCL6B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human B cell CLL/lymphoma 6 member B protein(BCL6B) ELISA kit
Description: A competitive ELISA for quantitative measurement of Human B cell CLL/lymphoma 6 member B protein(BCL6B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human B- cell CLL/lymphoma 6 member B protein, BCL6B ELISA KIT
Description: A sandwich ELISA for quantitative measurement of Rat B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Rat B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Rat B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Canine B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Canine B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Canine B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Porcine B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Porcine B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Porcine B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human B-Cell CLL/Lymphoma 2 Like Protein 2 (Bcl2L2) Protein
Description: A sandwich ELISA for quantitative measurement of Goat B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Goat B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Goat B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Human B-Cell CLL/Lymphoma 2 Like Protein (Bcl2L) Protein
Description: A sandwich ELISA for quantitative measurement of Mouse B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Mouse B cell lymphoma 6 protein(BCL6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
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